The first-line drugs for the treatment of urticaria are antihistamines. Antihistamines can be divided into first- and second-generation antihistamines. The first generation includes cetirizine, ketotifen, and paracetamol. Second generation antihistamines include cetirizine, loratadine, epalmatine, etc. The two types of drugs can be used in combination or alternately. In order to prevent resistance to antihistamines from occurring in the long-term application, a different type of drug can be replaced when the application of a certain drug is ineffective. Patients with chronic urticaria that has been controlled should be maintained and relieved by a gradual reduction in dosage to discontinuation of the drug. Glucocorticoids as second-line drugs for urticaria treatment are generally used in acute urticaria of acute severity or in patients with urticaria where antihistamines are ineffective, but long-term use should be avoided to prevent the side effects of glucocorticoids. Drugs that reduce vascular permeability include vitamin C and calcium gluconate, often used in conjunction with antihistamines. Patients with urticaria caused by infectious factors may be treated with concomitant oral antibiotics as appropriate.