Adrenal nodules are mainly categorized into functional and non-functional nodules. Functional nodules may have manifestations such as endocrine hormone abnormalities, such as cortisolism, which is manifested as full moon face, buffalo back, and hirsuteness, etc.; aldosteronism, which is manifested as low potassium, hypertension, etc.; and pheochromocytoma, which is manifested as paroxysmal hypertension and rapid heartbeat. And non-functional nodules are without clinical symptoms. Functional adrenal nodules commonly lead to hypertension, diabetic tendency, menstrual irregularities, sexual dysfunction and so on. Depending on the secretion function of adrenal nodules, the clinical manifestations are also different, for example, there can be mostly palpitations, pallor, sweating, severe hypertension, but also buffalo’s back, nausea, vomiting and so on. Once adrenal nodules are detected, endocrinology is needed to test the secretion function of adrenal nodules. According to the benign or malignant nature of the adrenal nodule, the presence or absence of secretory function, etc., the specialist physician will give the appropriate treatment plan after the interview.