Is pathology necessary to confirm the diagnosis of Paget’s disease of the breast? How to do it? Pathological examination is usually done to find paget cells, and the tests needed are: 1) cytological examination of nipple discharge and skin exudate smear; 2) pathological examination of superficial skin tissue section of the lesion; 3) biopsy of superficial skin tissue excision of the lesion; 4) cytological biopsy of breast lump puncture or pathological examination of excision. Are there any non-invasive pathological examination methods? Among them, nipple discharge and skin exudate smear for cytologic examination are non-invasive, but the diagnostic positivity rate is low. Can a negative pathology of the nipple areola lesion exclude paget disease? Can a positive test confirm the diagnosis 100%? Even if the pathology of the nipple areola lesion is negative, Paget disease of the breast cannot be ruled out. Sometimes there are no obvious nipple areola changes and often there may be no biopsy. So in this case, the pathology biopsy should be changed and biopsied again. A positive biopsy can of course clearly confirm the diagnosis, as long as paget cells are found. Do I need to be hospitalized for the pathological examination? How long does it take for the wound to heal after biopsy? Usually, hospitalization is not required, i.e., it is done on an outpatient basis. A biopsy of the mass is usually healed in about two weeks.