Weakly positive antikeratin antibody suggests the possibility of rheumatoid arthritis, but it should be analyzed in conjunction with the patient’s clinical symptoms, rheumatoid factor and other laboratory tests, as well as joint X-rays and other imaging tests, to assess whether the patient has rheumatoid arthritis. Antikeratin antibody is one of the specific antibodies for rheumatoid arthritis, which is of great significance in diagnosing early rheumatoid arthritis, but its sensitivity is relatively low. Antikeratin antibodies may be more likely to be positive during the active phase of rheumatoid arthritis. If weakly positive antikeratin antibodies are detected, they should be analyzed in conjunction with the patient’s clinical symptoms, such as symmetric small joint pain, morning stiffness, etc., laboratory tests such as rheumatoid factor, anti-cyclic citrullinated peptide antibodies, anti-nuclear antibody profile, and antimutant citrullinated protein antibodies, as well as imaging tests such as joint X-rays. Clinically, when you find a positive antikeratin antibody, it is recommended that you consult the rheumatology and immunology department of a regular hospital, and follow the doctor’s instructions to standardize the diagnosis and treatment.