Toothpaste can help to remove dirt, eliminate bad breath and make the mouth refreshing. Toothpaste on the market at present is basically divided into two categories: one is ordinary type, the main ingredients are rubbing agent, descaling agent, foam agent, binding agent, holding agent, flavoring agent, flavoring agent, preservative, etc.; one is curative type, in addition to the above ingredients, it also contains therapeutic effect of herbs, western medicine, active enzymes, sodium fluoride, etc.. However, the therapeutic toothpaste inhibits the growth of some normal oral flora while inhibiting germs, disrupting the ecological balance of oral flora and leading to flora imbalance; and long-term use will also make some bacteria resistant to drugs. Therefore, in order to ensure oral health, dentistry experts recommend frequent replacement of toothpaste type, replacement time to January is appropriate, generally no oral disease, fluoride toothpaste and ordinary toothpaste can be used monthly alternately, but also occasionally interspersed with a few weeks of drug toothpaste.