The most difficult clinical differentiation between Crohn’s disease and intestinal tuberculosis is that of ileal tuberculosis. The most common site for the development of Crohn’s disease is the ileocecal region and the small intestine, and although the entire intestine can develop, the ileocecal region and the small intestine are the most common sites. However, it is also in this area that intestinal tuberculosis is likely to occur.1 Since intestinal tuberculosis is most often found in areas rich in lymphatic tissue, it is also likely to occur in the ileocecal region and the small intestine. This is the time to differentiate it from intestinal tuberculosis. Intestinal tuberculosis usually has a history of tuberculosis, or tuberculosis in the family, or a lesion in the lung. The pathology of intestinal tuberculosis is usually positive for Mycobacterium tuberculosis, and the pathology appears to be caseous granuloma, whereas intestinal Crohn’s disease is non-caseous granuloma. From these points, it is basically possible to identify whether it is intestinal tuberculosis or Crohn’s disease.2. It should also be distinguished from leukoaraiosis, which is actually a lesion of the intestinal vasculature and can also appear as an ulcer in the ileocecal region. In addition to ulcers in the intestine, this disease can also present with recurrent ulcers in the mouth and even in the anus, which are also indications for differentiation.3. Lymphoma of the intestine should also be differentiated from Crohn’s disease.4. Infectious diseases of the intestine, such as schistosomiasis or amebiasis, and ischemic enteropathy, or infectious intestinal diseases such as fungal or viral infections, should also be differentiated.