First of all, medicines should be given to reduce fever in advanced stage of lung cancer, and then relevant examination should be carried out to clarify the cause of the disease, and treatment should be carried out according to the cause of the disease. The most common cause of high fever in advanced stage of lung cancer is combined with infection, at this time, anti-infection treatment should be carried out in time, and drugs should be given to lower the temperature at the same time, such as ibuprofen, indomethacin, lysergic acid and so on can be chosen. According to the patient’s infection situation, relevant indexes, such as blood routine, C-reactive protein, calcitoninogen, etc., to carry on anti-infection treatment. Intracranial metastasis in some patients may also lead to persistent high fever, which can be evaluated according to CT or MRI of the head, and if metastasis exists, targeted radiotherapy and other treatments are needed. Although the advanced stage of lung cancer cannot be cured, active symptomatic treatment can improve the quality of life and even prolong the survival period.