Estriol ointment is a topical ointment that is not harmful to the body, but some people may experience adverse reactions such as localized itching, burning sensation, and breast discomfort during use. Estriol cream is a topical estrogen-based cream that is very widely used. It can be used to treat vaginal dryness, itching, and painful intercourse, as well as frequent urination, mild urinary incontinence, painful urination, and in postmenopausal patients before and after vaginal surgery and other vaginal operations. There are some groups of people who are prohibited from taking the drug, such as those with prior breast cancer, undiagnosed vaginal bleeding, and untreated endometrial hyperplasia. There are also some patients who may experience localized itching, burning sensation, breast discomfort and other adverse reactions with the use of estriol ointment, which require prompt discontinuation of the medication and a visit to the hospital. The specific use of estriol ointment should be used correctly under the guidance of a doctor to avoid adverse reactions to self-medication.