When gout-induced big toe pain occurs, patients can take oral colchicine for symptomatic pain relief. Colchicine can inhibit the chemotaxis of leukocytes in the joints and quickly reduce the inflammation of the joints and provide pain relief. However, some patients do not tolerate colchicine and experience abdominal pain and diarrhea as side effects after taking it. When the patient’s pain is relieved, in order to avoid another painful attack of the big toe, continuous uric acid-lowering medication is needed during the interval when the joint is not painful, because only by continuously reducing the blood uric acid to below 360μmol/L can the recurrent attacks of gout be reduced, and febuxostat can be chosen for uric acid-lowering treatment.