Insulin resistance is generally effective with metformin, which can increase insulin sensitivity and improve insulin resistance, it is recommended to use the drug under the guidance of a doctor. Metformin Metformin is an insulin sensitizer, which can inhibit intestinal glucose absorption, hepatic gluconeogenesis and output, increase the uptake and utilization of glucose in tissues, increase insulin sensitivity, improve insulin resistance, and have the effect of lowering high blood sugar. Metformin as a first-line drug for type 2 diabetes mellitus, used in patients with type 2 diabetes mellitus who are not satisfied with dietary control alone, especially those who are obese and accompanied by hyperinsulinemia, with this drug not only has the effect of lowering blood glucose, but also may have the effect of reducing body weight and hyperinsulinemia. Therefore, metformin can improve insulin resistance by reducing the weight of obese type 2 diabetic patients and increasing the insulin sensitivity of peripheral tissues, taking the drug need to pay attention to the adverse drug reactions and side effects, and if you are not feeling well, you need to consult a doctor in time.