The cost of chemotherapy for esophageal cancer without complications is about 7,000-8,000 RMB before medical insurance payment and about 2,000 RMB after medical insurance reimbursement. If there are serious complications in the treatment, such as platelets and white blood cells are severely reduced, platelet transfusion is needed, and the cost is 20,000-30,000 RMB; if combined with lung infection, leukocyte-raising drugs are needed, the cost is higher. Patients and family members need to be prepared accordingly before treatment, and doctors will try to avoid serious complications for patients. Therefore, the cost of one cycle of chemotherapy for esophageal cancer patients should be determined on a case-by-case basis.