Often patients will say, “Doctor, I feel a lump here, is it a lymph node or is it cancer? Indeed, there is some reason to have such a concern. The incidence of cancer is increasing in modern society, and the probability that patients can find signs of cancer by self-examination is also increasing. Lymphatic metastasis is the main way of metastasis for most cancers. Different parts of cancer will cause lymph node metastasis in different parts, which will manifest as lymph node enlargement. The morphology of specific lymph node enlargement shows progressive enlargement, mostly painless, hard to touch, less mobile, and nearly round in shape. Different parts of the body correspond to different tumors. For example, swollen lymph nodes in the neck may be tumors of the nasopharynx and thyroid gland, while swollen lymph nodes in the left supraclavicular region may be esophageal cancer or stomach cancer. Enlarged right supraclavicular lymph nodes may be lung cancer, enlarged axillary lymph nodes may be breast cancer, enlarged inguinal lymph nodes may be rectal cancer, etc. If there are abnormal enlargement of lymph nodes in several parts of the body, especially if there is partial fusion, it is necessary to be alert to the possibility of malignant lymphoma, and if necessary, puncture biopsy or lymph node removal biopsy should be performed. In the case of enlarged lymph nodes with recurrent low-grade fever, the possibility of lymphatic tuberculosis should be alerted. Of course, it is not that the enlarged lymph nodes are cancerous; on the contrary, most of the cases are false alarms. Infections of the body surface or deep tissues, such as upper respiratory tract infections, gingivitis or even a small pimple can cause swelling of lymph nodes. The key is to keep an eye on the swollen lymph nodes and seek medical attention when you have doubts.