After taking azithromycin instead of coughing seriously may be insufficient dosage of medication, non-sensitive bacteria pathogenic or non-infectious diseases and other reasons. 1. Insufficient dosage: If the cough caused by sensitive bacterial infection is too small, azithromycin dosage is not effective in controlling the disease, leading to disease progression and worsening of the cough. 2. Non-sensitive bacteria cause disease: azithromycin is mainly effective for cough caused by Streptococcus pneumoniae, mycoplasma, chlamydia and other pathogen infections. If the cough is caused by non-sensitive pathogen infection, azithromycin is ineffective, causing cough aggravation. 3. Cough caused by non-infectious diseases: Cough may be caused by allergies or other reasons such as gastroesophageal reflux, patients taking azithromycin is not able to control the condition, causing cough aggravation. Cough aggravation can also be caused by other reasons, it is recommended to consult a doctor in a timely manner, improve the examination, clarify the cause of the disease, and standardize the treatment under the guidance of the doctor.