What types of Y chromosome microdeletions can occur

  The types of Y chromosome microdeletion are mainly as follows: 1. Y chromosome short arm microdeletion, clinical manifestation of azoospermia, small testes, abnormal spermatogenesis function due to testicular dysplasia, which leads to infertility.  2, Y chromosome long arm microdeletion, clinical manifestation of azoospermia or oligospermia, some patients with basically normal sexual function, sometimes with premature ejaculation.  3, Y chromosome microdeletion chimeric, clinical manifestations are all oligospermia, sexual dysfunction degree is different, wife is not pregnant, or early pregnancy embryo stop development and spontaneous abortion.  4, X and Y chromosome microdeletion combined type, that is, both X chromosome long arm and Y chromosome long arm have microdeletion, clinical manifestations of primary infertility, small testes, azoospermia, secondary sexual characteristics dysplasia; may have cumulative genetic effect or synergistic genetic effect of the two microdeletions, and affect testicular dysplasia, sperm production disorder.  5, Y chromosome microdeletion translocation type, the translocation both involve Y chromosome microdeletion, clinical manifestations are spermatogenesis disorder, oligospermia.  6, Y chromosome inter-arm inversion, because the long arm of Y chromosome is obviously smaller, it can also be included in Y chromosome microdeletion, the patient is a carrier of Y chromosome inter-arm inversion, the phenotype is normal, the clinical manifestation is oligospermia, his wife’s pregnancy was aborted once due to embryonic development stagnation, and then no pregnancy.