The generic name for Pyrexone is Trimethoprim Econazole Cream and the generic name for Dakine is Miconazole Nitrate Cream. Tretinoin Econazole Cream can be rubbed on perianal eczema and Miconazole Nitrate Cream is not recommended. Trimethoprim Econazole Cream is also an antifungal drug, which has a certain therapeutic effect on dermatitis and eczema accompanied by fungal infections or a tendency to fungal infections, and it can stop itching well and help the condition recover. Miconazole nitrate cream belongs to the antifungal medication, suitable for skin fungi, yeast and other fungi caused by the skin, nails or toenails and other diseases. Perianal eczema is a chronic recurrent inflammatory skin disease around the anus that causes intense itching and is not directly related to fungal infections; antifungal medications cannot be used. Trimethoprim Econazole Cream may have adverse reactions, such as burning sensation of the skin, itching, pins and needles, etc. Long-term use will cause skin atrophy, capillary dilatation, hyperpigmentation and so on. Perianal eczema is recommended to go to the hospital in a timely manner, under the guidance of the doctor to choose the appropriate medication for treatment, can not blindly use their own medication to avoid adverse consequences.