Surgical treatment of myasthenia gravis

  1.How to correctly understand myasthenia gravis? Is myasthenia gravis harmful?  Myasthenia gravis is an autoimmune disease with dysfunction of neuromuscular junction transmission. The main clinical characteristics are that the affected muscles are easily fatigued and can be partially recovered after rest. All muscles in the body can be involved, mainly the eye muscles. If the respiratory muscles are involved, myasthenia gravis may become critical or even life-threatening.  Traditional medicine has long been documented and researched, and generations of doctors believe that the pathogenesis of myasthenia gravis is mainly due to spleen and stomach disease. The treatment advocates starting with spleen nourishment, using a set of treatment method of nourishing the spleen and benefiting the qi throughout, and using a set of treatment method of treating the symptoms, making strong muscle strength drink to rule it, and according to the theory of the five organs, adding and subtracting with the evidence to treat its concurrent evidence.  2.What are the treatment methods for myasthenia gravis? What is the effect?  At present, the treatments for myasthenia gravis are: surgery, western medicine (including anticholinesterase drugs, hormones, immunosuppressants), plasma replacement therapy, and Chinese medicine. However, these means individually have their own advantages and disadvantages. Overall, most doctors are currently limited by their specialties and take a single means, and the treatment effect is not very satisfactory.  3.Why do we need surgery for myasthenia gravis? How is the surgery done? Is it very traumatic?  Clinical and basic medicine show that about 90% of patients have pathological changes in the thymus gland, and recent studies show that the thymus gland has a key role in the pathogenesis of myasthenia gravis, and myasthenia gravis may develop into a generalized type in adult patients, and surgery can prevent the progression of the disease.  Patients with myasthenia gravis with thymoma should receive surgical treatment, except for contraindications to surgery, and should undergo thymic contouring, i.e. complete removal of the tumor, thymus and possible thymic lobules (up to the meridian, down to the pericardial diaphragm angle, and on both sides to the phrenic nerve) and anterior mediastinal fat. The transsternal median sternal incision thymectomy currently adopted by our department is the most complete clearance of all surgical approaches and can effectively prevent the most troubling recurrence problem for surgeons.  Due to the advancement of anesthetic surgical techniques the surgery can be completed in about 1-2 hours and is not very invasive. Patients who are worried about chest scars can choose thoracoscopic surgery, and the absence of scars after surgery is its biggest advantage, but the surgery is difficult to achieve complete contouring of thymic tissue, which may lead to recurrence of symptoms after surgery, surgical failure and other consequences.  4.How is the surgical effect of myasthenia gravis? What do I need to pay attention to after myasthenia gravis surgery?  Most studies have shown that the surgical effect of myasthenia gravis is significantly better than medical treatment, so it is also the preferred treatment option for myasthenia gravis. However, it usually takes about one year after thyme contouring to see the effect of surgery, so the standard medication for myasthenia gravis is still needed after surgery, and the use of hormones or immunosuppressants is critical, in addition to improving symptoms with bromopyridostigmine.  5.Some patients are found to have thymoma with symptoms of myasthenia gravis, how to treat them?  Most of the patients in this part are adults. Combined with experience and related literature, this type of myasthenia gravis has poor surgical treatment and still requires long-term medication after surgery with poor prognosis. However, surgery is still necessary because thymoma will keep increasing in size and needs to be removed as soon as possible, otherwise the tumor will increase in size and cause compression symptoms, or it may be a malignant thymoma that invades adjacent organs leading to compression symptoms in the short term, such as difficulty in breathing or even breath-holding and gradual worsening of chest pain.