With C. difficile infection, dietary recommendations are light and easily digestible. C. difficile is strictly anaerobic, very sensitive to oxygen and very difficult to culture in vitro. Since the human intestinal tract is a relatively anaerobic environment, C. difficile normally colonizes the intestinal tract, but can multiply under certain special circumstances, leading to diseases such as pseudomembranous enteritis or antibiotic-associated diarrhea. When the patient suffers from enteritis caused by C. difficile, the diet needs to be light and easy to digest, mainly taking fluid, semi-fluid, starchy food, such as congee, noodles and so on. This kind of food is well digested and can quickly provide the body with the required energy and carbohydrates without increasing the burden on the intestinal tract. The diet needs to be controlled and needs to be less oily, while in conjunction with the symptoms, some saline or oral rehydration salts can be taken orally to replenish the body’s electrolytes. Fiber content should not be too high, so it is not advisable to eat coarse grains, such as rye, oats, corn and so on, when you have diarrhea. This type of food tends to speed up intestinal peristalsis, leading to worsening of diarrhea, as well as producing adverse symptoms such as intestinal flatulence. Clostridium difficile infection must cooperate with the doctor to actively treat, adopt scientific and reasonable program, for the best therapeutic effect.