1.Abnormal hormone secretion syndrome Excessive hormone secretion syndrome, such as excessive growth hormone causing acromegaly; hormone secretion hyposecretion syndrome. When the non-functional tumor enlarges and the normal pituitary tissue is damaged, amenorrhea is caused by reduced gonadotropin secretion. Infertility or impotence often occurs earliest and is more common.
2.Tumor compression of peripituitary tissues (1) Nerve fiber irritation.
(2) Compression of optic nerve, optic cross and optic nerve bundle Patients present with loss of vision, visual field defects and fundus changes; other compression syndromes.
Pituitary stroke is an acute neuroendocrine lesion caused by the sudden onset of intra-tumoral hemorrhage, infarction and necrosis of pituitary tumors, resulting in the expansion of the tumor. The clinical manifestation of acute pituitary stroke mainly depends on the direction of tumor expansion and the degree of hemorrhage and pituitary destruction. If the hemorrhage is rapid and large, directly affecting the hypothalamus, the patient may be accompanied by cerebral edema and obvious increase of intracranial pressure.
4, other hypopituitarism manifestations Any cause of the anterior pituitary hormone secretion deficiency caused by a series of clinical manifestations is called hypopituitarism, the disease is divided into two categories: primary and secondary, the former is due to the destruction of pituitary secretory cells, the latter is due to hypothalamic lesions resulting in lack of stimulation of the pituitary gland, the former is clinically common.