Knee joints itch like ants crawling need to be treated according to the cause, the common factors are calcium deficiency, restless leg syndrome, knee synovitis, etc. The treatment methods include general treatment, physiotherapy, medication and surgery. 1. Calcium deficiency: Calcium deficiency can lead to poor bone growth and itchy joints in adults. Daily consumption of calcium-rich foods, such as seafood, soy products and dairy products. More sunshine and proper exercise will help to maintain joint function. 2. Restless Legs Syndrome: It mainly involves the nervous system of the legs, and the patients often show numbness, ants sensation, burning sensation, tingling sensation and other discomforts in both lower limbs. The performance is most obvious during sleep or quiet state, which seriously affects sleep. Mild can be relieved by exercise, massage, etc., serious need to cooperate with drug therapy, such as dobutazide, pramipexole, gabapentin and so on. 3. Knee synovitis: Early on, there will be symptoms such as fluctuating feeling in the knee joint and limitation of activities, and CT, MRI and arthroscopy can find joint effusion and damage. Physiotherapy such as ultrashort wave and spectrum can relieve symptoms; drugs such as methotrexate, celecoxib and etoricoxib can control inflammation and relieve pain; arthroscopic lesion debridement can be considered if conservative treatment is ineffective. Knee joints itch like ants crawling there may be other reasons, such as knee joints have obvious ants, swelling and pain, it is recommended to consult a doctor in a timely manner, improve the examination to clarify the cause of the disease, to give targeted treatment or treatment. The above drugs should also be used under the guidance of a doctor.