The vaccination age at which adults can be vaccinated is usually the full age range, including 80-year-olds. However, the specific ability to vaccinate depends on the physical condition of the elderly, and vaccination decisions can only be made carefully after a full understanding of the health situation. According to data from clinical studies, the vaccine’s protective ability for 80-year-olds is similar to that of the general population with good safety, and 80-year-olds are a group with a high incidence of serious illness and death after contracting infectious diseases. Therefore, vaccination is recommended provided that the vaccination requirements are met. 80-year-olds generally need to exclude contraindicated conditions before vaccination, including being in the acute phase of diseases such as fever and infection, being in the acute attack of chronic diseases, the presence of neurological diseases such as epilepsy, or suffering from uncontrolled serious chronic diseases such as severe liver and kidney diseases, hypertension not controllable by drugs, complications of diabetes mellitus malignant tumors, etc. The above conditions should not be vaccinated. If the above contraindications are ruled out, vaccination can usually be administered. However, it is still recommended to inquire at the local vaccination department, as the requirements may vary from region to region. In addition, vaccinations should not be administered to 80-year-olds if they have an allergy to any of the active ingredients or additives of the vaccine, or if they have had a severe allergy, such as shock, angioneurotic edema, or respiratory distress, during a previous vaccination of this type.