Glucose-lowering drugs can effectively reduce blood sugar, but the specific type of glucose-lowering drugs is not good, and it is necessary for endocrinologists to develop individualized glucose-lowering programs according to the patient’s blood sugar value, pancreatic function, degree of insulin resistance, liver and kidney function, etc. Clinically used hypoglycemic drugs are as follows: 1, sulfonylurea: for type 2 diabetic patients with basically normal liver and kidney function, commonly used drugs are glimepiride, but these drugs can induce hypoglycemia, the current clinical application is gradually reduced; 2, biguanide: type 2 diabetes preferred drugs, with insulin sensitizing effect, representative drug is metformin; 3, alpha-glucosidase inhibitors: for high postprandial glucose Diabetic patients, relatively high safety, but some patients can appear obvious gastrointestinal symptoms, such as abdominal distension, representative drugs are acarbose, voglibose; 4, enteroglucagon class: that is, GLP-1 receptor agonist, is a new type of drug (injection), can be used for obese type 2 diabetes patients, in lowering blood sugar at the same time can promote weight loss; 5, thiazolidinediones: has the effect of reducing insulin resistance 5. Thiazolidinediones: have the effect of reducing insulin resistance, such as pioglitazone, the application of which requires assessment of the patient’s cardiac function; 6. SGLT-2 inhibitors: renal sugar excretion, can reduce fasting and postprandial blood glucose, the application process should pay attention to avoid urinary tract infection, the representative drug is Dagliflozin; 7. Diabetic patients, in addition to the occurrence of acute complications of diabetes are generally treated with insulin. Although the effect of drugs to lower sugar is better, but patients should also pay attention to a reasonable diet and appropriate amount of exercise in daily life, to control blood sugar within the normal range.