Gallbladder removal can not cause high blood sugar and high blood fat, blood sugar is mainly regulated by insulin, blood fat is mainly hormone regulation, and has little to do with the gallbladder. The role of the gallbladder is mainly to store bile, concentrate bile, and secrete protective fluid from the gallbladder. Although the gallbladder helps digestion and absorption of fat, after gallbladder removal, the digestion of fat will not be affected too much, and the digestion of lipids can be carried out by directly discharging bile from the liver; blood glucose is regulated by insulin in the body, and blood glucose may be temporarily elevated due to postoperative stress after cholecystectomy, but it will return to normal very soon. Hyperglycemia and hyperlipidemia may be related to postoperative dietary habits, such as excessive intake of sugars and fats, or the patient’s own metabolic abnormalities of sugars and lipids. After cholecystectomy, symptoms such as high blood glucose and high blood fat need to consult a doctor in time, complete the relevant examinations, and standardize the treatment under the guidance of the doctor.