The ingredients of Nosyntho are sacubitril valsartan, which can be used for the treatment of high blood pressure, and the antihypertensive effect of the drug varies from person to person, so it is not possible to assess whether it is good or bad. Sacubitril valsartan belongs to a combination preparation that includes sacubitril and valsartan. Sacubitril belongs to the enkephalinase inhibitor, which can inhibit the degradation of brain natriuretic peptide in the body, and play the role of antihypertensive through diuretic dilatation of peripheral blood vessels, and can reduce the load on the heart, which can be used in the treatment of heart failure. Valsartan belongs to angiotensin II receptor antagonist, and the main indication is hypertension. Sacubitril valsartan can be used in the treatment of most patients with hypertension, and is especially suitable for the treatment of hypertension with cardiac insufficiency. The therapeutic effect of the drug varies from person to person, and the effect may have some differences from patient to patient, and it is not possible to assess the effect of the drug. Adverse reactions of sacubitril valsartan include angioedema, impaired renal function, increased creatinine, increased blood potassium, etc. It is contraindicated in patients with allergy to the drug components, ACEI- or ARB-related angioedema, idiopathic angioedema, and severe hepatic impairment. If you suffer from hypertension, you should seek medical advice and use the drug under the guidance of a physician.