Pancreatic cancer is known as the “king of cancers” and has a very poor prognosis. The typical biological characteristics of pancreatic cancer are vasculophilic, neurophilic and metastatic. According to the results of a study, 80% of pancreatic cancer patients have microscopic metastases in the retroperitoneal connective tissue and nerve tissue, and the extent of tumor infiltration has far exceeded what we can remove at present. In fact, a significant proportion of pancreatic cancers have formed microscopic or subclinical metastases before the formation of distant metastases visible to the naked eye, and therefore, these tumors show distant metastases within a short period of time after surgery. Surgical procedures are the only possible cure for this disease. All surgical procedures are complex and are landmark procedures at the level of the general surgeon or hepatobiliary-pancreatic-splenic surgeon. For radical pancreatic cancer at the head of the pancreas, surgical resection includes not only the head and neck of the pancreas, but also the distal stomach, gallbladder, extrahepatic bile duct, all of the duodenum and part of the jejunum, as well as removal of the associated regional lymph nodes. Cancer in the body of the pancreas requires either caudal resection or total pancreatectomy. Caudal pancreatic resection includes removal of the pancreatic body site, the spleen, and, if radical, the left adrenal gland, the anterior lobe of the left perinephric fatty sac, and the associated regional lymph nodes. Due to the high trauma of this type of surgery, fatal complications such as postoperative hemorrhage and pancreatic leakage are likely to occur. Therefore, the clinical experience of surgeons who perform these surgeries is extremely demanding. Generally speaking, surgeons who perform more than 100 of these surgeries will have significantly fewer surgical complications, significantly less trauma, and significantly longer patient survival.