Thickening of liver particles is considered as fatty liver in most patients because with the improvement of living standard, high fat diet, lack of exercise and obesity are all high response factors for fatty liver. In such patients, the symptoms of fatty liver, including thickening of liver particles, can usually be reversed after exercise, lipid lowering, and proper regular living. If these details are not attended to, the condition can progress and can result in cirrhosis and even further deterioration. Coarse liver particles can also be considered as various types of hepatitis, cirrhosis, autoimmune liver disease, alcoholic liver, and liver changes caused by hepatic bile duct stones. Depending on the etiology, antiviral, hepatoprotective, and surgical treatments are available. Most patients can delay the progression of the disease, unless surgical diseases can be radically treated, many diseases of medical nature can only delay the development, and there is a possibility of further progression of hepatic granular enlargement, although the progress is delayed, the patient must be aware of this situation.