Blood pressure is normal in the morning and high in the afternoon, a condition that requires adjustment of the use of antihypertensive drugs. Blood pressure is a physiological indicator of the human body and is currently diagnosed as hypertension when it exceeds 140/90 mmHg. Blood pressure in people with hypertension can fluctuate over a 24-hour period, usually rising during the day and falling at night. If blood pressure is normal in the morning and increases in the afternoon, it is recommended that antihypertensive medication be used at noon each day to reduce afternoon hypertension when the medication is most effective. Antihypertensive medications should be chosen as long-acting extended-release formulations once daily. Options include amlodipine, enalapril, and irbesartan hydrochlorothiazide tablets. It is also important to monitor blood pressure levels to ensure that blood pressure is stable and up to standard over 24 hours.