This year, the topic of “acromegaly” is very hot, and “acromegaly” refers to patients with motor neuron disease. Although the incidence rate is very low, only (1-2)/100,000, but it must be said that motor neuron disease is the most destructive neurodegenerative disease both physically and mentally, it is generally only unilateral limb weakness at the beginning of the disease, the most common is finger movement and weakness, with the development of the disease, there will be the whole upper limb weakness, accompanied by muscle atrophy, gradually developed to the whole body, and finally destroy the human The entire motor system is destroyed and respiratory failure occurs fatally. The sensory system and cognitive functions are preserved during this process, which I think is what makes this disease extra cruel. Looking at the overwhelming topic of “acromegaly”, it reminds me of a case of motor neuron disease that I personally diagnosed a few years ago, when the word “acromegaly” was not yet in the public eye so frequently. The patient was my college friend’s high school math teacher, a very kind and good-tempered person, who was introduced by my classmate from Shenyang to see me. I remember clearly, that day I told his lover the final diagnosis, she cried in the office heartbreaking, the whole person squatting on the floor simply can not get up, I know she is actually a very subtle person, only to hear her mouth chanting, why so good people will get such a disease, too unfair. We did not directly tell the patient the bad news, but he should probably guess the result, but when he was leaving he kept smiling faithfully and thanking us, my heart was very unhappy and helpless, because I knew in my heart that most of this disease will develop respiratory failure within 5 years, good conditions can be on the ventilator to barely maintain life, if not, respiratory failure after the emergence of respiratory failure also means the end of life If not, respiratory failure will mean the end of life. After the diagnosis they returned to the local area, within a few months his lover called me to ask about the ventilator, only to learn that the machine for a period of time, after a long time without contact, at least five years have passed, a while ago received a text message, some surprise, perhaps in my heart did not expect them to last so long, many patients on the ventilator can live a long time, but the cost is huge, a single ventilator, monitors, nutrients and other basic maintenance costs per day. The basic maintenance costs such as ventilators, monitors, nutrients, etc. will cost thousands of dollars a day, not to mention the occasional lung infection and other complications, which should be a big burden for a working family like theirs. When I saw the text message, I couldn’t help but feel a shiver in my heart, and I couldn’t tell if I was moved by the couple’s love, their heartache for the patient, or their helplessness about the disease. She asked me if there were any new treatments for Mr. Li, who is now close to having only his eyeballs left to move. In fact, currently reported effective drugs such as Leroy and Coenzyme Q10 have long been used, and there are too many unknowns to explore for this disease. In the end, I did not reply, I think so she may still have some hope in her heart. There are many patients like Ms. Li lying in many hospital wards, and the majority of them should be suffering more than a death sentence, no one knows what they are thinking. I sincerely hope that one day we can find an effective cure for this disease. I also hope that the public and the society can give more material and spiritual support to the “frozen” people.