Roughness of the gastric mucosa is a description of the patient’s gastric mucosa during an e-gastroscopy. Under normal circumstances, the gastric mucosa is relatively smooth, while the rough gastric mucosa usually suggests the presence of lesions, such as: inflammation, intestinalization, tumors, and so on. During gastroscopy, if the gastric mucosa is found to be rough, the rough tissue can also be taken directly for pathologic biopsy to clarify the nature if necessary. If the examination result shows that it is caused by gastric inflammation, it is recommended to use medication, such as: omeprazole, bismuth potassium citrate and so on. If the examination results show the presence of gastric mucosal atrophy, enterosis, cancer, etc., it is necessary to cooperate with the doctor to give surgical treatment. After checking out the roughness of the gastric mucosa, it is recommended to consult a doctor in time, after the doctor’s interview, combined with clinical symptoms and other relevant auxiliary examination items, to comprehensively determine the cause of the disease, and according to the cause of the disease, follow the doctor’s instructions for treatment.