After taking Amoxicillin and Clarithromycin if observed no adverse symptoms can continue to home observation, if the body occurs discomfort promptly go to the hospital for treatment. Amoxicillin is a sensitive bacteria antibiotic for the treatment of systemic infections, usually does not produce disulfiram-like reaction with alcohol. Clarithromycin is a macrolide antibiotic that can be used to treat sensitive bacterial infections and usually does not react with alcohol. Drinking alcohol after taking amoxicillin and clarithromycin is unlikely to produce a reaction between the three, but alcohol should still be prohibited while taking the medication to avoid adverse events. If the drug has been taken with alcohol, this time should pay attention to home observation, drink more water to promote the metabolism of drugs and alcohol, if no adverse symptoms occur without special treatment, if the discomfort occurs immediately to the hospital emergency.