Toothache swelling is generally caused by periapical abscess, commonly used drugs have antibacterial drugs, such as metronidazole, analgesic drugs, such as aspirin and other drugs, as follows. 1. Antibacterial drugs: periapical abscesses are usually caused by anaerobic infections, the anaerobic bacteria have a killing effect of nitroimidazole drugs, such as metronidazole, periapical abscesses have a certain therapeutic effect. 2. Analgesic drugs: such as aspirin, ibuprofen and other non-steroidal anti-inflammatory analgesic drugs, through the inhibition of prostaglandin synthesis, can relieve inflammation and reduce pain. All of the above medications need to be under the guidance of a doctor. If the symptoms of tooth pain and swelling are serious, it is recommended to go to the hospital in time for treatment according to the cause of toothache.