Growth hormone was first approved for use in people with growth hormone deficiency, and later approved for use in children younger than fetal age, Turner syndrome, etc. Growth hormone has a good safety profile and was officially approved by the U.S. Food and Drug Administration (FDA), the most stringent agency in the world, in 2003 for use in non-growth hormone deficient people to increase their height. In 2003, the FDA officially approved growth hormone for the treatment of non-growth hormone deficient patients, the first of which must be safe and the second must be effective. Growth hormone has also been used to treat cardiovascular disease in recent years, and has been found to have good therapeutic effects in the fields of weight loss and anti-aging, and there is evidence in recent years that growth hormone is beneficial to intellectual development. In the United States and Japan, growth hormone treatment for growth hormone deficiency has been incorporated into national health plans, and the European Endocrine Society officially declared in 1993 that genetically recombinant human growth hormone (rhGH) has good safety and efficacy for the treatment of dwarfism. The pubertal state is a normal physiological process, and the peak secretion of growth hormone in adolescents during puberty is generally more than twice that of normal adults, and the total secretion in a day is more than three times that of normal adults. That is to say, the normal physiological state, growth hormone exponential increase will not affect health, and we treat the amount, and the exponential increase is still a certain gap. This is one of the theories on which growth hormone can be approved for use in people who are not growth hormone deficient. For people with growth hormone deficiency, which we used to call pituitary dwarfism, there are many dangers if growth hormone is deficient and not supplemented in time. It can cause not only dwarfism, but also osteoporosis, muscle and sexual dysplasia, susceptibility to aging, cardiovascular disease and metabolic abnormalities. Children with zinc and calcium deficiency need to be supplemented, why not growth hormone deficiency? It is only that growth hormone deficiency is less obvious, unlike diabetic patients and insulin deficiency, which can be fatal immediately if not supplemented in time. Since growth hormone is exogenous, redness and swelling at the injection site often occur. At the same time, since the growth rate of those who apply growth hormone was generally slow in the past, growth accelerates after use, and the need for thyroxine increases. Also, because growth hormone inhibits glucose metabolism, there may be occasional cases of slightly high blood glucose, both of which need to be reviewed regularly during medication. Other side effects include headache and joint pain, which are usually mild and will improve after a few days of dose reduction or discontinuation, and will be less pronounced after a period of gradual adaptation. Other serious side effects are extremely rare. Growth hormone does not promote bone age growth. Growth hormone is more often used in children with growth hormone deficiency. In such children, the bone age is often low, and after applying growth hormone to make the growth hormone basically normal, the backward bone age has a tendency to approach the normal bone age, which can be easily mistaken as promoting bone age growth. Some oral drugs in the society that promote height increase, their height increase is at the cost of excessive vinegar fine bone age development, but ultimately affect lifelong {. The amount of growth hormone secretion in patients with gigantism is often dozens or even hundreds of times that of normal people, and if growth hormone promotes bone age growth, patients with gigantism will not be able to become giants.