The medication for hypertension can be changed, for example, when the blood pressure is not well controlled and this antihypertensive medication is not suitable. According to the patient’s specific situation and the effect of the drug, as well as the tolerance of the drug, but also according to the patient’s economic situation and personal wishes, you can choose the appropriate antihypertensive drugs. The choice of antihypertensive drugs should start with small doses, and it is best to choose long-acting antihypertensive drugs, some of which can be used in combination, and the patient should be individualized. It can also prevent complications such as cardiovascular and cerebrovascular diseases. If the drug effect is not good, you can also consider the combination of drugs, such as the combination of two or more drugs, blood pressure > 160/100mmHg or more, you can two drug combination therapy, for example, the clinical often with two drugs, the combination of sartan and diphenhydramine, sartan and diuretic combination, but also can be a combination of low flat class and beta-blockers and so on.