Acne on both sides of the cheeks is generally referred to as acne, the patient can follow the doctor’s instructions to use medication, physical therapy, and should also strengthen the skin care. 1. Medication: When there is acne on both sides of the cheeks, patients can follow the doctor’s instructions to use 0.1% adapalene gel, retinoic acid cream and other retinoic acid drugs, but also apply benzoyl peroxide to achieve astringent, bactericidal effect; the application of the above medications, but also can be combined with the application of fusidic acid cream, erythromycin cream and other antibiotics to treat the disease. Some patients can also apply 15%~20% azelaic acid cream, 2.5% selenium disulfide lotion, etc., which has a therapeutic effect on acne and can also reduce post-inflammatory hyperpigmentation. In addition to medication, acne patients can take oral contraceptives, spironolactone and other anti-androgen drugs as prescribed by the doctor, but also feasible intradermal steroid hormone injection therapy. 2. Physical therapy: For lesions caused by acne, patients can seek medical treatment through photodynamic therapy, which also helps to reduce the inflammatory response. Some people with scarring can use laser therapy, such as intense pulsed light and fractional laser. 3. Enhance skin care: People with acne on both sides of the cheeks should adjust their work and rest and mentality to ensure sufficient sleep time and a happy mood. Pay attention to a light diet, avoiding cold, spicy and irritating foods. Patients should also pay attention to personal hygiene, do not squeeze the acne with their hands to avoid infection, and should wash the affected area with warm water every day. It is recommended that people with acne on both sides of the cheeks be treated with medication under the guidance of a physician, and not use drugs or prescriptions on their own.