When the patient wakes up in the morning, there are large black spots in the eyes and red eyes, which may be caused by vitreous clouding and conjunctivitis. 1. Vitreous clouding: the main symptom of vitreous clouding is the appearance of large black spots in front of the eyes, the vitreous body is originally a jelly-like structure, when there is degeneration, liquefaction, the patient can appear in front of the eyes, black spots, stripes or flocculent floaters. If patients use their eyes frequently, they may also have conjunctival congestion. 2. Conjunctivitis: When you wake up in the morning, there are large black spots in front of your eyes and your eyes are red, which may also be caused by conjunctivitis. Under the stimulation of inflammation, the patient may appear conjunctival congestion, edema, increased secretion and other discomfort symptoms, the patient may be manifested as red eyes. Patients may also experience other discomforts such as burning sensation, foreign body sensation, and pain. It is recommended that patients with dark shadows in front of the eyes with redness should seek prompt medical attention to evaluate their condition and follow the doctor’s instructions for treatment.