Tick bite can be diagnosed comprehensively based on clinical manifestations, serologic examination, pathogenic examination, imaging examination, etc., of which serologic and pathogenic examination are the most important methods. 1.Clinical manifestations. Tick is a small spider-like animal, after biting, it will be adsorbed on the skin to suck blood and lead to corresponding symptoms. The main symptoms are flu-like symptoms, such as muscle pain, headache, nausea and vomiting, fever, etc. Rashes can also occur; a small number of people may have allergic reactions. 2. Serologic examination. Serum specific antibody test can be conducted, if the serum antibody in the recovery period is at least four times higher than that in the acute period, tick bite can be diagnosed. 3. Pathogenetic testing. PCR can be performed on specimens of whole blood or blood cells, and tick bites can be diagnosed if specific nucleic acids of the pathogen are positive. 4. Imaging examination. It is mainly applicable to people with headache and other manifestations, to conduct head CT, MRI examination, etc., to exclude other head diseases; people with respiratory symptoms need to conduct lung CT examination, etc., to exclude other lung diseases. It is recommended that people with corresponding symptoms, rashes or sores should consult the doctor in time and undergo relevant examinations to clarify the diagnosis.