The co-administration of Cold and Fever Granules cannot be generalized, but the drugs should be selected according to the condition, such as ibuprofen, oseltamivir and other drugs can be selected according to the doctor’s instructions. Cold and heat particles have the effect of relieving the surface and clearing away heat, dispersing wind and dispersing cold. Used for wind-cold cold, cold (cold) body pain, headache and fever, runny nose, cough and dry throat. Adverse reactions include nausea, vomiting, diarrhea, abdominal pain, abdominal distension, abdominal discomfort, dry mouth, rash, itching, palpitations, allergic reactions, dyspnea, etc. It is contraindicated for those who are allergic to this product. Cold and flu use cold clear heat granules, according to the condition if the combination of high fever, can be combined with ibuprofen and other antipyretic drugs symptomatic treatment, allergic to ibuprofen, peptic ulcer or bleeding is prohibited, ibuprofen can be seen in abdominal pain, nausea, vomiting and other adverse reactions. If it belongs to influenza, it can be combined with oseltamivir granules anti-influenza treatment, it is forbidden for those who are allergic to the components of this product. This product can be seen vomiting, nausea, bronchitis, insomnia, dizziness and other adverse reactions. Specific medication should be used under the guidance of a doctor to avoid aggravating the condition.