Colorectal cancer combined with liver and lung metastasis is mainly treated by surgery, intervention, radiotherapy, targeted therapy, and immunotherapy. Colorectal cancer refers to malignant tumors occurring in the colon or rectum, which can metastasize to the liver. Colorectal combined liver metastasis is already in advanced stage, and the treatment is based on chemotherapy and radiotherapy as follows: 1. If the primary foci and liver and lung metastases can be resected, the two can be resected together; 2. If the primary foci can be resected but the metastases cannot be resected, palliative resection can be performed on the primary foci, and the metastases can be given interventional therapy (e.g., transvascular chemoembolization, radiofrequency ablation, injection of anhydrous alcohol, etc.) or local radiotherapy; 3. If the primary foci cannot be removed, “short-circuit” surgery or stoma surgery is feasible. In addition, after surgical treatment, patients need to choose chemotherapy, radiotherapy, targeted therapy, immunotherapy, etc. according to the situation. In conclusion, colorectal combined liver and lung metastases are in advanced stage and need comprehensive treatment. It is recommended to go to the regular hospital for a comprehensive assessment of the condition, choose the appropriate treatment plan according to the situation, and follow the doctor’s instructions to actively cooperate with the treatment, so as to avoid delaying the condition.