The bcl-2 gene, B-cell CLL/lymphoma 2, B-cell lymphoma/leukemia-2 gene, is an oncogene that is highly expressed in a variety of tumor cells, including breast, lung, and colorectal cancers. High bcl-2 expression enhances the migratory and invasive potential of these cells, and when the level of bcl-2 expression decreases, a decrease in cellular invasive ability also occurs, suggesting that bcl-2 plays a role in promoting cellular invasion. The bcl-2 molecule has long been recognized as a key anti-apoptotic factor, and with the discovery of the role of bcl-2 in tumor metastasis, it is expected to provide new ideas for tumor therapy and metastasis inhibition. However, the specific molecular mechanism by which bcl-2 promotes tumor metastasis has not yet been fully clarified, and the development of targeted drugs against bcl-2 has yet to be a breakthrough , so a great deal of work is still needed from researchers.