The causes of 5-hydroxytryptamine (irregular medical term: pentazocine) insufficiency include emotional problems, sleeping conditions, seasonal problems, etc. 1. Emotional problems: If you are in a state of prolonged tension, anxiety and irritability, it can lead to a prolonged state of excitation of the brain nerves and frequent transmitter activity, thus consuming a certain amount of 5-hydroxytryptophan, resulting in 5-hydroxytryptophan deficiency. 2. Sleep condition: 5-hydroxytryptamine is usually synthesized during sleep. Continuous sleep deprivation and poor sleep quality will reduce the synthesis of 5-hydroxytryptamine. 3. Seasonal problems: sun exposure can also promote the synthesis and secretion of 5-hydroxytryptamine. For example, in the fall and winter seasons, the sunlight appears to be reduced, and there are fewer opportunities for sunbathing, which will lead to a decrease in 5-hydroxytryptamine secretion. If the 5-hydroxytryptamine deficiency occurs for a long time and is accompanied by depression, anxiety, obsessive-compulsive, hypochondriac and various gastrointestinal symptoms, it is recommended to go to the hospital as soon as possible to consult a doctor to clarify the cause of the disease and then carry out targeted treatment.