If the total protein is slightly high, it is a normal phenomenon and does not need special treatment, regular review can be done. If the total protein is persistently high, it is considered to be caused by systemic lupus erythematosus, macroglobulinemia, multiple myeloma, etc. Patients should take glucocorticosteroids, immunosuppressants, diphosphonates and other medicines for the cause of the disease, which can alleviate the symptoms of the disease. 1. Systemic lupus erythematosus (SLE): high total protein is considered to be caused by SLE. Patients should take oral glucocorticosteroids, such as prednisone, hydrocortisone, dexamethasone, etc., or oral immune agents, such as azathioprine, methotrexate. 2. Macroglobulinemia: high total protein is also considered to be caused by macroglobulinemia. Patients can take oral prednisone, dexamethasone and other glucocorticoid drugs according to medical advice. 3. Multiple myeloma: high total protein is also considered to be caused by multiple myeloma. Patients can take bisphosphonates such as clodronic acid and disodium pamidronate according to the doctor’s instruction, and oral glucocorticosteroids such as prednisone and hydrocortisone if there is infection. There are many reasons leading to high total protein, and patients are advised to take relevant treatment measures actively.