Fluid oozing from neck incision after esophageal cancer surgery may be caused by wound infection, anastomotic fistula and so on. It can be treated by medication and surgery. Fluid oozing from neck incision after esophageal cancer surgery can be caused by wound infection, which can be treated by oral medication such as cefoxitin and cefamandole under doctor’s instruction, due to the fact that patients do not change gauze in time for the oozing fluid after surgery, or the immunity is low caused by too much postoperative fasting, and the poor absorption of nutrients in the body, which results in the infection of the incision, and fluid oozing from incision may occur. Fluid oozing from neck incision after esophageal cancer surgery may be caused by anastomotic fistula, which belongs to postoperative complications of esophageal cancer and is due to local tissue ischemia and necrosis, poor healing at the anastomosis causing redness and swelling of the incision, pressure and pain, subcutaneous emphysema, and fluid exudation, etc. It can be treated by drainage through drain tube, surgical treatment and so on. Therefore, patients with fluid exuding from neck incision after esophageal cancer surgery should clarify the cause of disease as soon as possible and carry out standardized treatment under the guidance of doctors and do not use medicine by themselves.