Prednisone and teriflunomide can theoretically be used together. No relevant experiments have found that teriflunomide and prednisone have contraindications, if the patient’s condition requires, can be combined after excluding the contraindications of the corresponding drugs. Teriflunomide belongs to the immunosuppressant, the main indications for relapsing multiple sclerosis, the drug may interact with Repaglinide, rosiglitazone, warfarin, levonorgestrel, tizanidine and other drugs, which has not yet been found to have a contraindication to Teriflunomide and prednisone. Prednisone is a glucocorticoid drug, mainly used for autoimmune inflammatory diseases and allergic diseases, such as the patient’s condition requires prednisone and teriflunomide combination therapy, then exclude the contraindications of these two drugs can theoretically be combined with the two drugs. However, both drugs are immunosuppressive and hepatotoxic, so they should be used with caution in patients with co-infections and liver diseases. Prednisone and Teriflunomide should be used strictly under the guidance of a physician, and it is recommended that patients go to the relevant departments of regular hospitals for detailed counseling, do not self-medication.