Alexander Disease is a relatively rare disease, mainly due to abnormalities in the white matter of the brain patients with corresponding symptoms. Clinically, the most common is that babies can be born with a huge brain, and then after 1-2 years of life, they will show developmental delay, megalencephaly and quadriplegia, and will also have epileptic seizures. In general, there is no effective clinical treatment for Alexander disease, but only symptomatic treatment, such as anti-epileptic, anti-infection. Some of these Alexandrias also develop around the age of six, and can generally survive for more than ten years. The main symptoms are choking on water, dysarthria, ptosis, and also brainstem involvement. Intelligence may not be impaired, but there is a slow decline. Alexander’s disease is rare in clinical practice, and the cause of the disease is unclear.