High blood pressure and increased urinary creatinine may be caused by hypertensive nephropathy or by renal lesions. 1. Hypertensive nephropathy: long-term hypertension may lead to renal arteriosclerosis, which causes glomerular fibrosis, atrophy, and reduced blood supply to the kidneys, and ultimately cause renal function damage, leading to hypertension and increased urinary creatinine. 2. Renal lesions: nephritis, nephrotic syndrome and renal failure caused by various reasons may lead to glomerular necrosis, tubular atrophy, narrowing of renal arterioles, resulting in insufficient renal blood perfusion, which will lead to hypertension and elevated urinary creatinine and other symptoms. Whether hypertensive nephropathy, or renal lesions caused by elevated blood pressure and urinary creatinine should be actively treated, it is recommended that patients go to the hospital in a timely manner, under the guidance of the physician standardized diagnosis and treatment, so as to avoid delaying the condition.