Patients with membranous nephropathy suffer from urinary infection and need to be treated with anti-inflammatory drugs. Optional drugs such as levofloxacin, amoxicillin capsule, cefuroxime and so on. Urine culture test is recommended before using antibiotics, and then adjust the medication according to the drug sensitivity test. Stage II membranous nephropathy is a very common disease, clinical symptoms mainly include large amount of proteinuria, edema, hyperlipidemia, hypoproteinemia. The treatment involves the use of hormones and immune agents, currently the most commonly used are low-dose hormones and tacrolimus, while also taking Bering capsule to protect the kidneys, valsartan, Benadryl and other drugs to assist in reducing urinary protein. For patients with membranous nephropathy combined with urinary infection, first of all, we need to evaluate the patient’s glomerular filtration rate (GFR), according to the GFR to choose the appropriate antibiotics, commonly used antibiotics, such as levofloxacin, amoxicillin capsule, cefuroxime, cefixime, etc., the use of antibiotics need to be perfect before the use of urine culture + drug sensitivity test, and then later on according to the drug sensitivity test to choose sensitive drugs. In addition, in the absence of edema, it is recommended to drink more water, urinate more often, pay attention to rest, and avoid exertion. The above medication should follow the doctor’s prescription and should not be used without authorization so as not to aggravate the condition. It is recommended that patients with urinary infections in Stage II membranous nephropathy should consult regular hospitals in time and receive standardized treatment under the guidance of physicians.