Callus generally refers to callus, there is no best and fastest way to get rid of callus on the skin, but it can be removed through general treatment, drug treatment and physical therapy. 1. General treatment: patients with callus on the skin should avoid local pressure and friction, while maintaining local cleanliness, avoid tearing off the callus, triggering secondary infection. 2. Medication: patients are advised to use salicylic acid, urea cream and retinoic acid ointment as prescribed by the doctor, which can help to peel off and soften the callus. 3. Physical therapy: liquid nitrogen cryotherapy helps to treat callus, through liquid nitrogen freezing local, so that the affected tissue necrosis, so as to remove the callus. There are many ways to remove the callus on the skin, it is recommended that patients go to the regular hospital, with the doctor for standardized treatment.