Lung nodule surgery pleural effusion for six months, usually related to infection, trauma, hypoproteinemia and other factors, can be combined with the cause of the drug treatment, surgical treatment, general treatment and so on. 1. Infection: Infection and inflammation may cause pleural effusion after lung nodule surgery, and oral antibiotics, such as cephalosporin, azithromycin, amoxicillin, etc., should be taken as soon as possible. If the amount is large, drainage surgery should be performed as soon as possible. 2. Trauma: Surgical trauma is relatively large, and may cause stress reaction in a short period of time after surgery, thus inducing pleural effusion. If the amount of pleural effusion is relatively small, no special treatment is needed; if the amount is relatively large, puncture drainage can be performed directly. 3. Hypoproteinemia: mainly due to the long-term nutritional deficiencies of patients after lung nodule surgery, it is usually necessary to supplement nutrition in time and consume more high-protein foods, such as meat, eggs and milk, etc. If necessary, serum albumin should be supplemented. If necessary, supplemental serum albumin and other drugs, if the effect is not good, can consider doing pleural effusion drainage surgery and other treatment. The pleural effusion six months after the lung nodule surgery may also be other reasons, there may be a variety of reasons for a combination of causes, it is recommended to go to the hospital to check and analyze the cause of the disease before targeted treatment. The above drugs should be used under the guidance of a doctor, unauthorized use of drugs is prohibited.