Dry and rough hands may be caused by dry weather, dry eczema, ringworm, etc. Different treatments can be chosen according to the cause, such as general treatment and medication. 1. Dry weather: dry and rough hands may be caused by dry weather, dry weather can lead to the loss of moisture in the body, the hands will have dry and rough performance, at this time you can apply hand cream to keep the hands moist, in addition, when you go out, you can wear gloves to strengthen the local protection. 2. Dry eczema: dry and rough hands may also dry eczema, you can strengthen the local skin moisturizing at the same time, external glucocorticoid preparations, such as Dinaid cream, flumethasone, etc., if necessary, you can also take antihistamines to relieve the symptoms, such as cetirizine, loratadine and other drugs. 3. Ringworm: dry and rough hands may also be ringworm, patients can use topical antifungal drugs, such as ketoconazole cream, bifonazole cream and other antifungal treatment, if necessary, you can also take oral antifungal drug treatment. There are many reasons for dry and rough hands, you should go to the hospital in a timely manner, to clarify the cause of the disease, under the guidance of the doctor to carry out professional treatment, do not take medication without authorization, to avoid adverse reactions.