Hypo-differentiated lung adenocarcinoma is not necessarily advanced stage, it needs to be judged according to the size of the tumor and the degree of metastasis to other parts. Hypofractionated lung adenocarcinoma refers to the low differentiation of lung adenocarcinoma cells, which is very different from normal epithelial cells of lung glands in morphology and function, and the degree of malignancy is relatively high, but it can not be directly judged as advanced stage, and low differentiated cancer cells can also appear in the early and middle stages. Lung adenocarcinoma tumor is in advanced stage when it appears pleural metastasis or multiple metastasis in the whole body, such as brain, bone, liver and so on. When hypofractionated lung adenocarcinoma appears, patients need to actively cooperate with doctors for treatment, control the development of the disease as much as possible, adjust their mentality, timely replenish the nutrients needed by the body, and exercise appropriately. If there is any discomfort during the treatment period, the patient should inform the doctor in time to avoid adverse consequences.