Waking up with swollen eyes every day can be caused by physiologic or pathologic factors. Common pathological factors include bacterial conjunctivitis, blepharitis, and kidney disease. 1. Physiological factors: As the subcutaneous tissue of the eyelids is relatively loose, it is easy for water retention. If too much water or salt is ingested at night, it will cause water retention, which in turn manifests as swollen eyes. In addition, before menstruation, due to the increased secretion of estrogen, some women will also cause water retention under the eyelid skin, resulting in swollen eyes. 2. Pathologic factors: Some diseases may lead to waking up with swollen eyes. (1) Bacterial conjunctivitis: common clinical manifestations of conjunctival congestion, swelling, mostly accompanied by increased secretions and other symptoms, so into the patient woke up with swollen eyes every day, you can follow the doctor’s orders to use chloramphenicol, tobramycin and other eye drops for treatment. (2) blepharitis: also known as granuloma, belongs to the eyelid glands of an acute suppurative inflammation, usually manifested as local redness, swelling and heat and other symptoms, and even waking up every day, there will be eye swelling and pain and other adverse phenomena. If the localization has formed abscess, surgical incision and drainage of pus. (3) Kidney disease: It causes damage to the kidney tubules and their surrounding tissues, resulting in fluid retention in the body, which leads to the appearance of waking up with swollen eyes, and it is recommended to actively treat kidney disease. If waking up with swollen eyes, accompanied by other uncomfortable symptoms, it is recommended to consult a doctor in a timely manner to clarify the diagnosis and carry out targeted treatment.